Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies
详细信息 查看全文
- 作者：Sandra Giovanolia ; Ulrike Weber-Stadlbauera ; b ; Manfred Schedlowskic ; Urs Meyera ; b ; urs.meyer@vetpharm.uzh.ch" class="auth_mail" title="E-mail the corresponding author ; Harald Englerc
- 关键词：Autism ; Cytokines ; Inflammation ; Maternal immune activation ; Microglia ; Poly(I ; C) ; Schizophrenia ; Synapse
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：25-38
- 全文大小：2667 K
文摘
- •
Maternal poly(I:C) challenge induces presynaptic hippocampal deficits in adult offspring.
- •
Prenatal immune activation leads to postsynaptic hippocampal deficits in pubescence.
- •
Hippocampal IL-1β is increased in adulthood without signs of systemic inflammation.
- •
Synaptic deficits occur in absence of microglial anomalies.