Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation

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• 作者：Sarah J. Mancini^a ; Anna D. White^a ; Silvia Bijland^a ; ¹ ; Claire Rutherford^a ; Delyth Graham^a ; Erik A. Richter^b ; Benoit Viollet^c ; ^d ; ^e ; Rhian M. Touyz^a ; Timothy M. Palmer^f ; Ian P. Salt^a ; ^{Ian.Salt@glasgow.ac.uk}
• 关键词：Adipocyte ; AMP-activated protein kinase ; Inflammation ; Signalling
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：440
• 期：Complete
• 页码：44-56
• 全文大小：2751 K
• 卷排序：440

文摘

AMPK rapidly inhibits proinflammatory NFκB and JNK signalling in adipocytes. Mechanisms underlying AMPK-induced effects involve inhibition of IRAK4, IKK and MKK4 phosphorylation. AMPK concurrently inhibits JAK-STAT signalling in adipocytes. Adipose tissue from mice lacking AMPKα1 exhibit increased proinflammatory signalling.