Inducible expression of indoleamine 2,3-dioxygenase attenuates acute rejection of tissue-engineered lung allografts in rats
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- 作者：Ammar Ebrahimia ; Gholam Ali Kardarb ; LadanTeimoori Toolabic ; Hossein Ghanbarid ; Esmaeil Sadroddinya ; sadrodiny@sina.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：AEC ; Alveolar Epithelial Cells ; COPD ; chronic obstructive pulmonary disease ; ECM ; Extracellular matrix ; ELT IDO ; engineered lung tissues with IDO ; ELT ; Engineered Lung Slides ; H&E ; Hematoxylin & Eosin ; HPRT ; hypoxanthine phosphor ribosyl transferase ; IDO ; indoleamine 2 ; 3-dioxygenase ; IFNγ ; Interferon Gamma ; IHC ; immunohistochemistry ; MOI ; multiplicity of infection ; MSC ; mesenchymal stem cell ; PBS ; phosphate-buffered saline ; RANTES ; Regulated On Activation ; Normal T Cell Expressed and Secreted ; S
- 刊名：Gene
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：576
- 期：1
- 页码：412-420
- 全文大小：2098 K
文摘
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Acute rejection score of IDO+ allografts was significantly lower than controls.
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ECM proteins along with SAGM media could guide rat MSCs into type I and II AECs.
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Inducible expression of IDO significantly downregulated IFNɣ and TNF-α expression.
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Local IDO expression could upregulate FOXP3, a Tregulatory cell marker.
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RANTES were downregulated in IDO expressing allografts.