Design, synthesis, and mode of action studies of a mitomycin tetramer inducing double activations with a single probe
详细信息 查看全文
- 作者：Hyoung Rae Kim ; Yeon Kyeong Park ; Sang Hyup Lee ; sanghyup@duksung.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mitomycin tetramer ; Double activations ; Disulfide cleavage ; DNA alkylation ; DNA interstrand cross-link
- 刊名：Bioorganic & Medicinal Chemistry
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：24
- 期：18
- 页码：4023-4031
- 全文大小：982 K
文摘
- •
Design and synthesis of new mitomycins 9 and 10 containing cyclic disulfide and diol linkers, respectively.
- •
Successful induction of nucleophilic activation of mitomycin tetramer 9.
- •
Efficient formation of DNA ISC (DNA interstrand cross-link) products using 9.
- •
The first demonstration of the strategy of double activations with a single probe in mitomycin studies.