Dual C-H activations of electron-deficient heteroarenes: palladium-catalyzed oxidative cross coupling of thiazoles with azine N-oxides

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• 作者：Xiao-Pu Fu^a ; Qing-Qing Xuan^a ; Li Liu^a ; ; Dong Wang^a ; Yong-Jun Chen^a ; Chao-Jun Li^b ; ^{cj.li@mcgill.ca}
• 关键词：Double C&ndash ; H activations ; Cross-dehydrogenative coupling ; Thiazoles ; Azine N-oxides ; Copper(II) pivalate ; Electro-deficient heteroarenes
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：3 June, 2013
• 年：2013
• 卷：69
• 期：22
• 页码：4436-4444
• 全文大小：2624 K

文摘

The palladium-catalyzed, copper-promoted cross-dehydrogenative-coupling (CDC) of electron-deficient thiazoles with azine N-oxides through dual C-H activations was developed. It was found that copper(II) pivalate was an efficient dual-function reagent for the oxidative cross-coupling reactions, playing the roles of both an oxidant and a C-H bond activation promoter. This methodology provides a simple way to construct 2-thiazolyl pyridine moiety.