Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay

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• 作者：Robert S. Adcock^a ; Yong-Kyu Chu^a ; Jennifer E. Golden^b ; Dong-Hoon Chung^a ; ^c ; ^{dhchun01@louisville.edu}
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：138
• 期：Complete
• 页码：47-56
• 全文大小：1173 K
• 卷排序：138

文摘

We developed a CPE-based assay for Zika virus inhibitor screen. Zika virus is susceptible to several broad-spectrum antivirals including SaliPhe, CID 91632869, and NITD008. We screened the NIH Clinical Compound Collection, 727 compounds, using a dose response format with two Zika virus strains. The screen discovered 6-azauridine and finasteride as potential anti-ZIKV inhibitors. Zika virus shows the highest sensitivity to brequinar among pyrimidine synthesis inhibitors.