Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus

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• 作者：Anuradha Balasubramanian^a ; Tadahisa Teramoto^a ; Amol A. Kulkarni^b ; Apurba K. Bhattacharjee^a ; ^{ab3094@georgetown.edu} ; Radhakrishnan Padmanabhan^a ; ^{rp55@georgetown.edu}
• 关键词：In silico modeling ; Stereo-electronic profiles ; Molecular electrostatic potentials (MEPs) ; Renilla luciferase reporter replicon ; Autophagy ; Cathepsin B
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：141-150
• 全文大小：2197 K
• 卷排序：137

文摘

From the antiviral activity of twelve amodiaquine derivatives, an interaction pharmacophore model was developed. Based on the model three new antimalarials were identified and verified as potent inhibitors of dengue and Zika viruses. Mode of action of these compounds is through inhibition of autophagy, especially the lysosomal proteases. This current study may lead to repurposing of antimalarial drugs for treatment of flaviviral infections.