Integrated bioinformatics, computational and experimental methods to discover novel Raf/extracellular-signal regulated kinase (ERK) dual inhibitors against breast cancer cells
30 compounds were designed as novel Raf1/ERK dual inhibitors and tested for their antiproliferative activity. Compound 9d showed significant IC50 at sub-micromolar level both in kinase inhibitory and cell proliferation assays. Compound 9d induces mitochondria apoptosis. These can be considered as interesting lead molecules against breast cancer.