Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23 - dependent IL-17RC
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- 作者：Patricia R. Taylora ; Tracey L. Bonfieldb ; James F. Chmielb ; Eric Pearlmana ; c ; Eric.Pearlman@uci.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cystic fibrosis ; CFTR ; F508del ; Neutrophil ; IL-17A ; IL-17RC ; IL-17A receptor ; MMP9 ; Elastase ; Pseudomonas aeruginosa ; F508del mice
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：170
- 期：Complete
- 页码：53-60
- 全文大小：1167 K
文摘
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Il17a and Il17rc are expressed by sputum and blood neutrophils in cystic fibrosis.
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Neutrophil Il17a and Il17rc expression is associated with pulmonary exacerbation.
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Sputum elastase and MMP9 activity correlates with %IL-17 + ve neutrophils.
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BAL neutrophils from cystic fibrosis mice express Il17a.
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Neutrophil Il17rc expression is IL-23 – dependent.