Androgen biosynthesis during minipuberty favors the backdoor pathway over the classic pathway: Insights into enzyme activities and steroid fluxes in healthy infants during the first year of life from the urinary steroid metabolome
刊名:The Journal of Steroid Biochemistry and Molecular Biology
出版年:2017
出版时间:January 2017
年:2017
卷:165
期:part_PB
页码:312-322
全文大小:1086 K
卷排序:165
文摘
Male androgen biosynthesis shows a significant peak at week 7 during minipuberty. Androgens in minipuberty are (at least in part) produced through the backdoor pathway. Steroid enzyme activities in the first year of life are all age-, some sex-specific. Steroid enzyme ratios obtained from urine GC–MS are comparable between laboratories.