In this work, we present linear N-polycyclic systems that inhibits BVDV infection.
All derivates have been investigated for their anti-BVDV activity.
Several compounds showed micromolar activity against BVDV.
In silico/in vitro analysis offer a molecular rationale for the BVDV RdRp NS5B affinity.
Compound 6b emerged as a potent inhibitor of this Pestivirus.