Alleles and haplotypes of the interleukin 10 gene polymorphisms are associated with risk of developing acute coronary syndrome in Mexican patients

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• 作者：José ; Manuel Fragoso^a ; ^e ; ^{mfragoso1275@yahoo.com.mx"" rel=""nofollow} ; Maite Vallejo^b ; ^{maite_vallejo@yahoo.com.mx"" rel=""nofollow} ; Edith Alvarez-Le&#xf3 ; n^a ; ^{edalvaleo@yahoo.com"" rel=""nofollow} ; Hilda Delgadillo^c ; ^{hilda_car@yahoo.com"" rel=""nofollow} ; Marco Antonio Pe&#xf1 ; a-Duque^c ; ^{penmar@cardiologia.org.mx"" rel=""nofollow} ; Guillermo Cardoso-Salda&#xf1 ; a^d ; ^{gccardosos@yahoo.com"" rel=""nofollow} ; Carlos Posadas-Romero^d ; ^{cposadasr@yahoo.com"" rel=""nofollow} ; Marco Antonio Martí ; nez-Rí ; os^c ; ^{mtzrios@gmail.com"" rel=""nofollow} ; Gilberto Vargas-Alarc&#xf3 ; n^a ; ^{gvargas63@yahoo.com"" rel=""nofollow}
• 关键词：Acute coronary syndrome ; Genetic susceptibility ; Inflammation ; Interleukin 10 ; Polymorphisms
• 刊名：Cytokine
• 出版年：2011
• 出版时间：July 2011
• 年：2011
• 卷：55
• 期：1
• 页码：29-33
• 全文大小：188 K

文摘

Inflammation plays an important role in the pathogenesis of atherosclerosis and acute coronary syndromes (ACS). Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine that mediates the inflammatory process. The objective of the present study was to evaluate the role of IL-10 gene polymorphisms as susceptibility markers for ACS in Mexican patients. IL-10 promoter polymorphisms (positions −1082, −819, and −592) were analyzed by 5′ exonuclease TaqMan genotyping assays in 389 ACS patients and 302 healthy controls. ACS patients showed increased frequencies of IL-10-592 C allele and CC genotype when compared to healthy controls (pC = 0.0006, OR = 1.48 and pC = 0.022, OR = 1.56, respectively), whereas the frequencies of the A allele and AA genotype were decreased in patients (pC = 0.0006, OR = 0.68 and pC = 0.006, OR = 0.57, respectively). When the distribution of IL-10-592 genotypes was analyzed separately in women and men (patients and healthy controls), a different distribution of alleles and genotypes was observed only in the group of men. In this case, increased frequency of C allele (pC = 0.004, OR = 1.46) and decreased frequencies of A allele (pC = 0.004, OR = 0.68) and AA genotype (pC = 0.023, OR = 0.56) were observed in the group of patients when compared to healthy controls. Multiple logistic analyses by gender showed that male individuals with IL-10-592 CC + AC genotypes had 3.54-fold increased risk of developing ACS than individuals with AA genotype (p < 0.001). The analysis of linkage disequilibrium showed one (ACC) increased haplotype in patients as compared to healthy controls. The results suggest that IL-10 gene polymorphisms could be involved in the risk of developing ACS in the Mexican population.