ACVR1-Fc suppresses BMP signaling and chondro-osseous differentiation in an in vitro model of Fibrodysplasia ossificans progressiva
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- 作者：Jing Panga ; Yue Zuoa ; Yi Chenb ; Lige Songa ; Qi Zhua ; Jing Yua ; Chang Shana ; Zeling Caib ; Jijun Haoc ; Frederick S. Kapland ; Eileen M. Shored ; Keqin Zhanga ; keqzhang2007@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fibrodysplasia ossificans progressiva ; Heterotopic ossification ; BMP signaling ; ACVR1 ; ALK2
- 刊名：Bone
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：29-36
- 全文大小：1312 K
文摘
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A novel soluble recombinant ACVR1-Fc was generated.
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ACVR1-Fc could suppress dysregulated ACVR1 signaling and chondro-osseous differentiation.
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In vitro model for FOP based on HUVECs was established.
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A novel receptor-mediated approach to block ligand-mediated ACVR1 signaling holds promise in the treatment of FOP.