Simultaneous quantitation of hexacosanoyl lysophosphatidylcholine, amino acids, acylcarnitines, and succinylacetone during FIA-ESI-MS/MS analysis of dried blood spot extracts for newborn screening
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- 作者：Christopher A. Haynes ; cph7@cdc.gov" class="auth_mail" title="E-mail the corresponding author ; Ví ; ctor R. De Jesú ; s
- 关键词：Flow-injection analysis ; Tandem mass spectrometry ; Newborn screening ; Dried blood spot ; X-linked adrenoleukodystrophy
- 刊名：Clinical Biochemistry
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：49
- 期：1-2
- 页码：161-165
- 全文大小：365 K
文摘
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Newborn screening analyzes biomarkers in DBS to detect metabolic disorders.
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C26:0-LPC is a biomarker for X-ALD and other peroxisomal biogenesis disorders.
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A method was developed that added C26:0-LPC to dried blood spot analysis.
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The method uses a single punch, extraction, and analysis by FIA–ESI–MS/MS.
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C26:0-LPC, amino acids, acylcarnitines, and SUAC are simultaneously quantitated.