Distinct 1-monoacylglycerol and 2-monoacylglycerol kinase activities of diacylglycerol kinase isozymes
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- 作者：Yuriko Sato ; Chiaki Murakami ; Atsumi Yamaki ; Satoru Mizuno ; Hiromichi Sakai ; Fumio Sakane ; sakane@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：AGK ; acylglycerol kinase ; DG ; diacylglycerol ; DGK ; diacylglycerol kinase ; LPA ; lysophosphatidic acid ; MG ; monoacylglycerol ; MGK ; monoacylglycerol kinase ; PA ; phosphatidic acid ; PS ; phosphatidylserine
- 刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1864
- 期：9
- 页码：1170-1176
- 全文大小：766 K
文摘
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Type I–III DGKs (α, β, γ, δ, η, κ and ε) have relatively stronger 2-MGK activity than 1-MGK activity.
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Type IV DGKs (ζ and ι) only have negligible 1-MGK and 2-MGK activities.
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Type V DGK (θ) has stronger 1-MGK activity than 2-MGK activity.
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These differences may affect the pathophysiological functions of each DGK isozyme.