Synthesis and evaluation against Leishmania amazonensis of novel pyrazolo[3,4-d]pyridazinone-N-acylhydrazone-(bi)thiophene hybrids
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- 作者：Andrey P. Jacominia ; Michael J.V. Silvaa ; Raí ; G.M. Silvaa ; Davana S. Gonç ; alvesa ; Hé ; lito Volpatob ; Ernani A. Bassoa ; Fá ; vero R. Paulac ; Celso V. Nakamurab ; Maria Helena Sarragiottoa ; Fernanda A. Rosaa ; farosa@uem.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antileishmanial activity ; Pyrazolo-pyridazinone ; N-acylhydrazone ; Thiophene ; Trypanothione reductase
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：340-349
- 全文大小：887 K
文摘
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Synthesis of pyrazolopyridazinone-N-acylhydrazone-(bi)thiophene hybrids is presented.
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Antileishmanial activity of pyrazolo-pyridazinone core is evaluated for the first time.
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The formation of the hybrid was significant for antileishmanial activity.