Low-density lipoprotein as a biomarker for the mobilization of hematopoietic stem cells in peripheral blood

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• 作者：Tomoko Ishihara ; Seiji Mishima ; Rumi Kodama ; Isao Yoshino ; Erika Adachi ; Tamiko Suyama ; Hiroshi Shibata ; Takeshi Taketani ; Atsushi Nagai
• 关键词：LDL ; Cholesterol ; Hematopoietic stem cell ; Mobilization ; PBSCH
• 刊名：Transfusion and Apheresis Science
• 出版年：December, 2013
• 年：2013
• 卷：49
• 期：3
• 页码：539-541
• 全文大小：389 K

文摘

The predictor of hematopoietic stem cells (HSCs) mobilized in peripheral blood (PB) remains unknown. We retrospectively examined the relationship between serum cholesterol level and CD34-positive cells mobilized with granulocyte stimulating factor in PB. PB- mobilized CD34-positive cells were significantly higher in patients with high titers of total cholesterol and low-density lipoprotein cholesterol (LDL-C) than in patients with normal levels (average total cholesterol, 122.94 vs. 51.03/渭L, p < 0.05; average LDL-C 130.07 vs. 53.77, p < 0.05). Multivariable analysis showed that LDL-C significantly influenced PB-mobilized CD34-positive cells, suggesting that LDL-C may be an effective biomarker for mobilization of HSCs in PB.