Osteoarthritis (OA) is a whole-joint degenerative multifactorial disease.
OA pathogenesis is influenced by oxidative stress, aging, hormones, and lifestyle habits.
Disease-modifying regimens are yet not available for OA.
Understanding OA pathobiology should lead to the discovery of more effective treatments.
Unraveling deregulated signaling cascades in OA will aid the development of novel therapies.