Overexpression of soluble ADAM33 promotes a hypercontractile phenotype of the airway smooth muscle cell in rat
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- 作者：Yiyuan Duana ; Jiaoyue Longa ; Jun Chena ; Xuemei Jianga ; Jian Zhua ; Yang Jina ; Feng Lina ; Jun Zhonga ; Rong Xua ; Lizheng Maoc ; Linhong Denga ; b ; dlh@cczu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; denglh@cqu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Asthma ; Airway hyperresponsiveness (AHR) ; Airway smooth muscle cells ; A disintegrin and metalloproteinase 33 (ADAM33) ; Hypercontractile phenotype ; Rho/ROCK pathway
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：349
- 期：1
- 页码：109-118
- 全文大小：1681 K
文摘
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sADAM33 overexpression enhances the stiffness, traction force and contractility of ASMCs.
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sADAM33 overexpression promotes a hypercontractile phenotype of ASMCs.
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The hypercontractile phenotype transition was largely mediated via Rho/ROCK pathway.
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ADAM33 knock-down had little effect on the stiffness, traction force and contractility of ASMCs.