Association between ADAM33 S2 and ST+4 polymorphisms and susceptibility to asthma: A meta-analysis

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• 作者：Gwan Gyu Song ; Jae-Hoon Kim ; Young Ho Lee ; ^{lyhcgh@korea.ac.kr}
• 关键词：ADAM33 ; a disintegrin and metalloproteinase domain 33 ; ORs ; odds ratios ; CIs ; confidence intervals ; H&ndash ; W ; Hardy&ndash ; Weinberg ; F ; fixed effects model ; R ; random effects model
• 刊名：Gene
• 出版年：2013
• 出版时间：15 July, 2013
• 年：2013
• 卷：524
• 期：1
• 页码：72-78
• 全文大小：674 K

文摘

Objective

The aim of this study was to determine whether ADAM33 (a disintegrin and metalloproteinase domain 33) polymorphisms confer susceptibility to asthma in different populations.

Methods

We performed a meta-analysis on the association between the ADAM33 S2, ST+4, F+1, S1, and V4 polymorphisms and asthma.

Results

Thirteen studies in ten reports, which included 4942 patients and 7933 controls, were available for the meta-analysis. Meta-analysis stratified by ethnicity indicated an association between the ADAM33 S2 2 allele and asthma in Europeans (OR = 0.912, 95 % CI = 0.851-0.977, p = 0.009). Meta-analysis revealed an association between asthma and the ADAM33 ST+4 2 allele (OR = 0.783, 95 % CI = 0.762-0.999, p = 0.048). Stratification by ethnicity indicated an association between the ADAM33 ST+4 polymorphism and asthma in Asians. Stratification by age indicated an association between the ADAM33 ST+4 2 allele and asthma in adults (OR = 0.863, 95 % CI = 0.782-0.964, p = 0.008). However, no association was found between asthma and the ADAM33 F+1, S1, and V4 polymorphisms.

Conclusions

This meta-analysis demonstrates that the ADAM33 S2 polymorphism confers susceptibility to asthma in Europeans and the ADAM33 ST+4 polymorphism is associated with asthma in Asians and adults.