Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis
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- 作者：Torsten Schrö ; der1 ; 2 ; David Kucharczyk1 ; Florian Bä ; r1 ; René ; Pagel1 ; 4 ; Stefanie Derer1 ; Sebastian Torben Jendrek1 ; 4 ; Annika Sü ; nderhauf1 ; Ann-Kathrin Brethack1 ; Misa Hirose3 ; Steffen Mö ; ller3 ; 11 ; Axel Kü ; nstner3 ; 12 ; Julia Bischof3 ; Imke Weyers4 ; Jö ; rg Heeren5 ; Dirk Koczan6 ; Sebastian Michael Schmid1 ; Senad Divanovic7 ; Daniel Aaron Giles7 ; Jerzy Adamski8 ; 9 ; 10 ; Klaus Fellermann1 ; Hendrik Lehnert1 ; Jö ; rg Kö ; hl2 ; 7 ; Saleh Ibrahim3 ; Christian Sina1 ; Christian.Sina@uksh.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：NAFLD ; Steatohepatitis ; Mitochondrial gene polymorphism ; Mitochondrial dysfunction ; Lipid metabolism ; TNFα
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：5
- 期：4
- 页码：283-295
- 全文大小：3627 K
文摘
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C57BL/6J-mtFVB/N mice (mt-ATP8, nt7778 G/T) display hepatic mitochondrial dysfunction.
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C57BL/6J-mtFVB/N mice display alterations in hepatic energy metabolism.
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C57BL/6J-mtFVB/N mice show no spontaneous hepatic steatosis or inflammation.
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C57BL/6J-mtFVB/N mice are susceptible to diet induced NASH.
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Study demonstrates causative role of mitochondrial dysfunction for NASH development.