Fractionation of Heteromorpha arborescens var abyssinica (Apiaceae) leaf extracts based on polarity leads to a marked change in cytotoxicity that may yield a commercially useful product
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- 作者：M. Adamu1 ; V.P. Bagla2 ; J.N. Eloff ; kobus.eloff@up.ac.za" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heteromorpha arborescens var abyssinica ; Selectivity index ; Cytotoxicity ; Anthelmintic ; Antimicrobial ; Fractionation
- 刊名：South African Journal of Botany
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：103
- 期：Complete
- 页码：36-40
- 全文大小：219 K
文摘
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H. arborescens had the best anthelmintic activity of several species previously examined.
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The crude extract was too toxic to test in animal experiments.
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Solvent–solvent fractionation of the crude extract decreased the cytotoxicity up to 50-fold.
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This did not affect the antifungal or anthelmintic activity of the butanol fraction.
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The fractionation yielded a potentially useful product with a selectivity index of more than 3.