Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction
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- 作者：Carolyn M. Macicaa ; carolyn.macica@quinnipiac.edu" class="auth_mail" title="E-mail the corresponding author ; Helen E. Kingb ; c ; H.E.King@uu.nl" class="auth_mail" title="E-mail the corresponding author ; Meina Wangd ; meina.wang@yale.edu" class="auth_mail" title="E-mail the corresponding author ; Courtney L. McEachond ; courtney.mceachon@yale.edu" class="auth_mail" title="E-mail the corresponding author ; Catherine W. Skinnerb ; catherine.skinner@yale.edu" class="auth_mail" title="E-mail the corresponding author ; Steven M. Tommasinid ; steven.tommasini@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：XLH ; Pregnancy ; Lactation ; Carbonate ; Phosphate ; Cortical bone remodeling ; Vitamin D ; Osteoporosis ; Mineral metabolism ; MMP-13
- 刊名：Bone
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：59-69
- 全文大小：1628 K
文摘
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We investigated the skeletal effects during reproduction in a mouse model of compromised mineral homeostasis.
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HYP mice had dramatic increases in intracortical porosity characterized by elevated serum PTH and MMP-13.
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Chronic abnormal serum biochemistries that characterize XLH return to within the normal range during pregnancy.
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HYP and wild-type mice had increased carbonate ion substitution in the bone mineral matrix during pregnancy and lactation.
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This form of mineral turnover provides mineral without osteoclast resorption in cortical bone during periods of high demand.