Knock-down of synapsin alters cell excitability and action potential waveform by potentiating BK and voltage-gated Ca2+ currents in Helix serotonergic neurons
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- 作者：O. Brenesa ; b ; oscar.brenes_g@ucr.ac.cr" class="auth_mail" title="E-mail the corresponding author ; oscar.brenesgarcia@edu.unito.it" class="auth_mail" title="E-mail the corresponding author ; D.H.F. Vandaelc ; d ; &dagger ; ; E. Carbonec ; d ; P.G. Montaroloa ; e ; M. Ghirardia ; e
- 关键词：AHP ; after hyperpolarization ; ANOVA ; analysis of variance ; AP ; action potential ; asRNA ; antisense RNA ; EGTA ; ethylene glycol tetraacetic acid ; Em ; resting membrane potential ; helSyn ; Helix synapsin ; helSynKD ; Helix synapsin knock-down ; HEPES ; 4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid ; IFF ; instantaneous firing frequency ; ISI ; interspike interval ; KO ; knock-out ; MFF ; mean firing frequency ; Rin ; input resistance ; RRP ; readily releasable pool ; SFA ; spike frequency adaptation ; Syn ; synapsi
- 刊名：Neuroscience
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：311
- 期：Complete
- 页码：430-443
- 全文大小：1903 K
文摘
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Cell excitability of single synapsin-silenced neurons was analyzed in vitro.
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Synapsin-silenced single neurons showed an increased intrinsic excitability.
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Increased Ca2+ currents are related with faster firing in synapsin-silenced cells.
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Increased BK currents are associated with faster firing in synapsin-silenced cells.