Simultaneous assessment of LS in all four cardiac chambers was performed in patients with cardiac amyloidosis, those with nonobstructive HCM, and control subjects.
LS in each chamber was significantly depressed in patients with both LVH phenotypes compared with control subjects.
Four-chamber LS was significantly associated with MACEs in patients with cardiac amyloidosis.
Chamber-specific strain analysis may be useful to assess the total cumulative burden of cardiac dysfunction in patients with cardiac amyloidosis.