Insights from Preclinical Choice Models on Treating Drug Addiction

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• 作者：Matthew L. Banks¹ ; ^{Matthew.Banks@vcuhealth.org} ; S. Stevens Negus¹
• 关键词：choice ; addiction ; preclinical model ; drug self-administration ; substance-use disorder
• 刊名：Trends in Pharmacological Sciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：38
• 期：2
• 页码：181-194
• 全文大小：2292 K
• 卷排序：38

文摘

Substance-use disorders are a global public health problem that arises from behavioral misallocation between drug use and more adaptive behaviors maintained by nondrug alternatives (e.g., food or money). Preclinical drug self-administration procedures that incorporate a concurrently available nondrug reinforcer (e.g., food) provide translationally relevant and distinct dependent measures of behavioral allocation (i.e., to assess the relative reinforcing efficacy of the drug) and behavioral rate (i.e., to assess motor competence). In particular, preclinical drug versus food ‘choice’ procedures have produced increasingly concordant results with both human laboratory drug self-administration studies and double-blind placebo-controlled clinical trials. Accordingly, here we provide a heuristic framework of substance-use disorders based on a behavioral-centric perspective and recent insights from these preclinical choice procedures.