Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts
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- 作者：Rajashree A. Deshpande1 ; Ji-Hoon Lee1 ; Sucheta Arora1 ; Tanya T. Paull1 ; 2 ; tpaull@utexas.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：64
- 期：3
- 页码：593-606
- 全文大小：3217 K
文摘
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The MRN complex introduces endonucleolytic cuts in DNA adjacent to 5′ adducts
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Nbs1 promotes MR exonuclease at adduct sites but blocks resection of open ends
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MRN endo- and exonuclease activity targets both strands of DNA close to the adduct
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MRN endonuclease activity at blocked ends is stimulated by CtIP