Polycyclic aromatic hydrocarbons and postmenopausal breast cancer: An evaluation of effect measure modification by body mass index and weight change

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• 作者：Nicole Niehoff^a ; ^{nicolen@live.unc.edu} ; Alexandra J. White^b ; Lauren E. McCullough^c ; Susan E. Steck^d ; Jan Beyea^e ; Irina Mordukhovich^f ; Jing Shen^g ; Alfred I. Neugut^h ; ⁱ ; Kathleen Conway^a ; Regina M. Santella^g ; Marilie D. Gammon^a
• 关键词：Polycyclic aromatic hydrocarbons ; Breast cancer ; Obesity ; Weight gain ; Adducts
• 刊名：Environmental Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：17-25
• 全文大小：287 K
• 卷排序：152

文摘

Examined whether obesity modifies associations between PAHs and breast cancer. PAH-DNA adducts more strongly associated with breast cancer if overweight or obese. There was suggestive modification by obesity for a few other measures of PAHs. Extent of modification was similar for BMI and weight gain.