Exercise preconditioning prevents MCT-induced right ventricle remodeling through the regulation of TNF superfamily cytokines
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- 作者：Rita Nogueira-Ferreiraa ; b ; Daniel Moreira-Gonç ; alvesb ; c ; danielmgon@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ana Filipa Silvab ; José ; Alberto Duartec ; Adelino Leite-Moreirab ; d ; e ; Rita Ferreiraa ; Tiago Henriques-Coelhob ; henriques.coelho@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Exercise training ; Heart failure ; Pro-inflammatory cytokines ; Pulmonary arterial hypertension ; Right ventricle muscle
- 刊名：International Journal of Cardiology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：203
- 期：Complete
- 页码：858-866
- 全文大小：1187 K
文摘
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Exercise preconditioning prevents PAH-induced right ventricle dysfunction.
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This beneficial effect seems to be related with the prevention of cardiac hypertrophy, fibrosis and MHC isoform switch.
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Exercise preconditioning also modulates TWEAK/NF-κB signaling and proteolysis.
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The protective phenotype promoted by exercise preconditioning can be maintained for several days after cessation of exercise.