Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells
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- 作者：Shun Shimobabaa ; Saeko Tagaa ; Risa Akizukia ; Asami Hichinoa ; Satoshi Endoa ; Toshiyuki Matsunagaa ; Ryo Watanabeb ; Masahiko Yamaguchib ; Yasuhiro Yamazakib ; Junko Sugatanib ; Akira Ikaria ; ikari@gifu-pu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; EGFR ; epidermal growth factor receptor ; HEMA ; poly-2-hydroxyethyl methacrylate ; KO ; knockout ; MAP ; mitogen-activated protein ; MMP ; matrix metalloproteinase ; NSCLC ; non-small cell lung cancer ; PDK1 ; 3-phosphoinositide-dependent protein kinase-1 ; PI ; propidium iodide ; PI3K ; phosphatidylinositol-3 kinase ; SCLC ; small cell lung cancer ; SDS-PAGE ; sodium dodecyl sulfate-polyacrylamide gel electrophoresis ; S.E.M. ; standard error of the mean ; TER ; transepitheli
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1863
- 期：6
- 页码：1170-1178
- 全文大小：1947 K
文摘
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Claudin-18 is absent in human lung cancer tissue.
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Claudin-18 decreases cell proliferation and motility in lung adenocarcinoma cells.
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Claudin-18 decreases phosphorylation of PDK1 and Akt.
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Claudin-18 binds to PDK1 and decreases its nuclear localization.
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Loss of claudin-18 expression may induce abnormal cell proliferation and motility in the lung.