Claudin-18 is absent in human lung cancer tissue.
Claudin-18 decreases cell proliferation and motility in lung adenocarcinoma cells.
Claudin-18 decreases phosphorylation of PDK1 and Akt.
Claudin-18 binds to PDK1 and decreases its nuclear localization.
Loss of claudin-18 expression may induce abnormal cell proliferation and motility in the lung.