Estrogen receptor beta as target for colorectal cancer prevention
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- 作者：Cecilia Williamsa ; b ; c ; Cecilia.Williams@scilifelab.se" class="auth_mail" title="E-mail the corresponding author ; Alfredo DiLeod ; Yaron Nive ; Jan-Å ; ke Gustafssona ; c
- 关键词：CRC ; colorectal cancer ; ER ; estrogen receptor ; CIMP ; CpG island methylator phenotype ; FAP ; familial adenomatous polyposis ; IBD ; inflammatory bowel disease ; RR ; relative risk ; OR ; odds ratios
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：372
- 期：1
- 页码：48-56
- 全文大小：596 K
文摘
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Estrogen exposure decreases the risk of colorectal cancer.
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Experimental evidence supports activation of ERβ in prevention.
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ERβ regulates DNA repair and apoptosis through p53 signaling.
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ERβ repressed oncogenes and metastasis.
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Phytoestrogens activate ERβ and show therapeutic efficacy.