Dietary l-methionine supplementation mitigates gamma-radiation induced global DNA hypomethylation: Enhanced metabolic flux towards S-adenosyl-l-methionine (SAM) biosynthesis increases genomic methylation potential
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- 作者：Vipen Batra ; batravipen@gmail.com" class="auth_mail ; Poonam Verma
- 关键词：Diet ; Metabolism ; DNA methylation ; l-methionine ; Radiation toxicity
- 刊名：Food and Chemical Toxicology
- 出版年：July 2014
- 年：2014
- 卷：69
- 期：Complete
- 页码：46-54
- 全文大小：1581 K
文摘
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Dietary l-methionine supplementation mitigates toxic effect of gamma (纬)-radiation on metabolic flux towards genomic DNA.
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Dietary l-methionine enrichment increased hepatic S-adenosylmethionine (SAM): S-adenosylhomocysteine (SAH) ratio.
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It influenced methionine adenosyltransferase and DNA methyltransferase-key enzymes regulating genomic DNA methylation.
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DNA methylation and 5-methyl-2′-deoxy cytidine quantification substantiated role of l-methionine against radiation-toxicity.
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Dietary l-methionine supplementation (2 g/kg AIN93M diet; 6 weeks) showed no toxic effect on liver.