Post-use assay of vaginal rings (VRs) as a potential measure of clinical trial adherence
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- 作者：Patrick Spencea ; pspence@ipmglobal.org" class="auth_mail" title="E-mail the corresponding author ; Annalene Nelb ; Nelië ; tte van Niekerkb ; Tiffany Derricka ; Susan Wilderc ; Brí ; d Devlina
- 关键词：Dapivirine vaginal ring ; Post-use assay ; Higuchi model ; In vivo drug release ; In vitro drug release ; Adherence model
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 June 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：94-100
- 全文大小：608 K
文摘
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Simulated use of dapivirine VRs showed no content changes after storage at RT or −20 °C.
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On average, about 4 mg of dapivirine is released in vivo after 28 days of VR use.
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Both in vivo and in vitro drug release conform to the Higuchi equation.
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Residual ring data should be used in conjunction with other PK measures for modeling adherence.