Bio-based polyurethane for tissue engineering applications: How hydroxyapatite nanoparticles influence the structure, thermal and biological behavior of polyurethane composites

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• 作者：Laí ; s P. Gabriel ; Dr^a ; Maria Elizabeth M. dos Santos^b ; André ; L. Jardini ; Dr^a ; Gilmara N.T. Bastos ; Dr^b ; Carmen G.B.T. Dias ; Dr^c ; Thomas J. Webster ; Dr^d ; ^e ; ^{th.webster@neu.edu} ; Rubens Maciel Filho ; Dr^a
• 关键词：Polyurethane ; Hydroxyapatite ; Tissue engineering ; Biodegradation ; Nanotechnology
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：13
• 期：1
• 页码：201-208
• 全文大小：1247 K
• 卷排序：13

文摘

In this work, thermoset polyurethane composites were prepared by the addition of hydroxyapatite nanoparticles using the reactants polyol polyether and an aliphatic diisocyanate. The polyol employed in this study was extracted from the Euterpe oleracea Mart. seeds from the Amazon Region of Brazil. The influence of hydroxyapatite nanoparticles on the structure and morphology of the composites was studied using scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), the structure was evaluated by Fourier transform infrared spectroscopy (FT-IR), thermal properties were analyzed by thermogravimetry analysis (TGA), and biological properties were studied by in vitro and in vivo studies. It was found that the addition of HA nanoparticles promoted fibroblast adhesion while in vivo investigations with histology confirmed that the composites promoted connective tissue adherence and did not induce inflammation. In this manner, this study supports the further investigation of bio-based, polyurethane/hydroxyapatite composites as biocompatible scaffolds for numerous tissue engineering applications.