The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells
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- 作者：Gin-Wen Chang1 ; 10 ; Cheng-Chih Hsiao2 ; 10 ; Yen-Ming Peng1 ; Felipe A. Vieira Braga3 ; Natasja A.M. Kragten3 ; Ester B.M. Remmerswaal2 ; 4 ; Martijn D.B. van de Garde2 ; Rachel Straussberg5 ; Gabriele M. Kö ; nig6 ; Evi Kostenis6 ; Vera Knä ; uper7 ; Linde Meyaard8 ; René ; A.W. van Lier3 ; Klaas P.J.M. van Gisbergen3 ; Hsi-Hsien Lin1 ; 9 ; 11 ; hhlin@mail.cgu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Jö ; rg Hamann2 ; 11 ; j.hamann@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：adhesion GPCRs ; cytotoxicity ; immune regulation ; NK cells ; transcription factor
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：24 May 2016
- 年：2016
- 卷：15
- 期：8
- 页码：1757-1770
- 全文大小：3488 K
文摘
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Hobit drives GPR56 expression in terminally differentiated NK cells
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Upon cellular activation, NK cells downregulate GPR56 expression
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GPR56 reduces NK-cell cytotoxicity and cytokine production
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GPR56 represses effector functions by forming a complex with CD81