Bupleurum chinense polysaccharide inhibit adhesion of human melanoma cells via blocking β1 integrin function
详细信息 查看全文
- 作者：Haibin Tonga ; b ; 1 ; ; Guiquan Jiangb ; 1 ; Dake Qic ; 1 ; Jingfeng Bid ; Dan Tiana ; Xingang Guana ; Sheng Zhenge ; Xin Suna ; sunxinbh@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bupleurum chinense ; Polysaccharide ; Integrin ; Fibronectin ; Focal adhesion
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：20 January 2017
- 年：2017
- 卷：156
- 期：Complete
- 页码：244-252
- 全文大小：1397 K
文摘
- •
BCP, water-soluble polysaccharide extracted from Bupleurum chinense, inhibited integrin-mediated adhesion of human melanoma A375 cells to fibronectin but had no effects on nonspecific adhesion to poly-l-lysine.
- •
BCP-treatment reduced β1 integrin ligand affinity and inhibited the adhesion-dependent formation of F-actin stress fibers and focal adhesions.
- •
The inhibition of BCP on integrin-mediated signaling is probably through its dephosphorylatory effects on focal adhesion kinase (FAK) and paxillin.
- •
Our current findings indicated that BCP may be a potential therapy for melanoma metastasis due to its inhibitory effects on integrin signaling.