The Sal-like 4 - integrin α6β1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells
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- 关键词：ECM ; extracellular matrix ; FA ; Focal adhesion ; FAK ; Focal adhesion kinase ; SALL4 ; Sal-like 4
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：1864
- 期：1
- 页码：76-88
- 全文大小：3585 K
- 卷排序：1864
文摘
SALL4 up-regulates integrin α6β1 expression at the transcription level. The SALL4 - integrin α6β1 network is required for a spindle-shaped morphology. The SALL4 - integrin α6β1 network activates focal adhesion dynamics. The SALL4 - integrin α6β1 network modulates Rho activation for cell migration.