A comparative investigation of mussel-mimetic sealants for fetal membrane repair

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• 作者：Michela Perrini^a ; ^b ; ^{perrini@imes.mavt.ethz.ch" class="auth_mail" title="E-mail the corresponding author} ; Devin Barrett^c ; Nicole Ochsenbein-Koelble^a ; Roland Zimmermann^a ; Phillip Messersmith^d ; Martin Ehrbar^a ; ^{martin.ehrbar@usz.ch" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Fetal membrane ; iPPROM ; Mussel-mimetic sealant ; Inflation test
• 刊名：Journal of the Mechanical Behavior of Biomedical Materials
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：58
• 期：Complete
• 页码：57-64
• 全文大小：2899 K

文摘

Towards the prevention of iatrogenic preterm premature rupture of the fetal membrane, two mussel-mimetic tissue adhesives (cT and cPEG) have been compared and qualified as possible sealants for membrane repair. Monotonic and cyclic inflation tests of repaired fetal membranes were carried out in order to investigate the performance of the glues under quasi-static, fast, and repeated loading. Finite element simulations of repaired and inflated synthetic membranes allowed to compare cT and cPEG under large deformations. Both adhesives seal the membrane well, resisting pressures higher than the intra-uterine baseline. Only under repeated mechanical load, as well as under fast and acute deformation of the membrane, the sealing performance has deteriorated. Even though cT loses adhesion to the deformed membrane, it is able to withstand high deformations and pressures without rupturing, while cPEG breaks.