Zn-doped etch-and-rinse model dentin adhesives: Dentin bond integrity, biocompatibility, and properties

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• 作者：Daphne Câ ; mara Barcellos^a ; Beatriz Maria Fonseca^b ; Cé ; sar Rogé ; rio Pucci^c ; Bruno das Neves Cavalcanti^d ; Erasmo De Souza Persici^e ; Sé ; rgio Eduardo de Paiva Gonç ; alves^c ; ^{sergio@fosjc.unesp.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Dental adhesive ; Dentin-bond agents ; Zinc oxide ; Methacrylates ; Matrix metalloproteinase inhibitors ; Collagen
• 刊名：Dental Materials
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：32
• 期：7
• 页码：940-950
• 全文大小：1719 K

文摘

This study assessed a 6 month resin/dentin bond's durability and cytotoxic effect of Zn-doped model dentin adhesives. The mechanical and physicochemical properties were also tested.

Methods

A model etch-and-rinse single-bottle adhesive was formulated (55 wt.% Bis-GMA, 45 wt.% HEMA, 0.5 wt.% CQ, 0.5 wt.% DMAEMA) and Zinc methacrylate (Zn-Mt) or ZnO nanoparticles (ZnOn) were added to the model's adhesive, resulting in three groups: Group Control (control model adhesive); Group Zn-Mt (1 wt.% Zn-Mt incorporated to adhesive) and Group ZnOn (1 wt.% ZnOn incorporated to adhesive). The microtensile bond strength (mTBS) was assessed after 24 h or 6 months in water storage. Mechanical properties (diametral tensile strength/DTS, flexural strength/FS, flexural modulus/FM, resilience modulus/RM, and compressive strength/CS) and physicochemical properties (polymerization shrinkage/PS, contact angle/CA, water sorption/WS, and water solubility/WS) were also tested. Cytotoxicity was evaluated with SRB biochemical assay.

Results

No significant difference in the DTS, FS, FM, CS, CA, WS, and WS were found when 1% of ZnOn or Zn-Mt was added to the model dentin adhesive. Group Zn-Mt decreased the RM of adhesive. Groups Zn-Mt and ZnOn decreased the PS of adhesives. Group ZnOn reduced the cytotoxicity of adhesive. Group ZnOn preserved mTBS after 6 months storage without degradation areas as seen by SEM analysis.

Significance

The 1 wt.% ZnOn may preserve the integrity of the hybrid layer and may reduce cytotoxicity and polymerization shrinkage of model dentin adhesive. The addition of Zn-Mt to the adhesive had no beneficial effects.