Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling
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- 作者：Lauren Reinkea ; b ; 1 ; Anna P. Lama ; d ; 1 ; Annette S. Flozaka ; d ; John Vargaa ; b ; j-varga@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Cara J. Gottardia ; c ; d ; c-gottardi@northwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fibrosis ; Metabolism ; Obesity ; Metabolic syndrome ; Cardiovascular disease ; Adiponectin ; Wnt ; Beta catenin signaling ; Lrp5/6 receptors
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：12 February 2016
- 年：2016
- 卷：470
- 期：3
- 页码：606-612
- 全文大小：1028 K
文摘
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Adiponectin inhibits Wnt-dependent β-catenin accumulation and target-gene expression.
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Adiponectin antagonizes Lrp6 phosphorylation.
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Inhibition of Lrp6 phosphorylation is independent of adiponectin receptors, AdipoR1 and R2.
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Ability adiponectin to inhibit β-catenin signaling has implications for its roles in tissue fibrosis and metabolic syndrome.