Association of adiponectin receptor 1 gene − 106 C > T variant with susceptibility to colorectal cancer

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• 作者：Touraj Mahmoudi^a ; ^{mahmouditouraj@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Khatoon Karimi^b ; Negar Karimi^a ; Hamid Farahani^c ; Hossein Nobakht^d ; Reza Dabiri^d ; Mohsen Vahedi^e ; Mohammad Reza Zali^a
• 关键词：ADIPOQ ; ADIPOR1 ; Colorectal cancer ; Gene polymorphism
• 刊名：Meta Gene
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：9
• 期：Complete
• 页码：210-214
• 全文大小：298 K

文摘

Colorectal cancer (CRC) is the fourth leading cause of cancer-related death around the world and accumulated evidence indicates the association between CRC and obesity and insulin resistance.

Objectives

Regarding the role of adiponectin in obesity and insulin resistance, we explored whether genetic variants in adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) are associated with CRC risk.

Materials and methods

ADIPOQ (rs2241766) and ADIPOR1 (rs2275738) gene variants were genotyped in 261 cases with CRC and 339 controls using PCR-RFLP method.

Results

In this study, no significant difference was observed for ADIPOQ gene rs2241766 variant between the cases and controls. However, carriers of the ADIPOR1 (rs2275738) “CC + CT” genotype compared with “TT” genotype occurred more frequently in the cases with CRC than the controls, and the difference remained significant after adjustment for age, BMI, sex, smoking status, NSAID use, and family history of CRC (P = 0.048; OR = 1.49, 95%CI = 1.01–2.20). Interestingly, after adjustment for confounding factors the ADIPOR1 “CC + TC” genotype compared with “TT” genotype was also associated with an increased risk for obesity in the cases (P = 0.040; OR = 1.86, 95%CI = 1.03–3.36).

Conclusions

Our findings suggest for the first time that the − 106 C > T (rs2275738) variant of ADIPOR1 gene may be a genetic contributor to CRC and obesity risk in the cases with CRC. However, further studies with bigger sample size are needed to validate these findings.