Fabrication of size-controlled linoleic acid particles and evaluation of their in-vitro lipotoxicity

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• 作者：Eun-Soo Lee^a ; ¹ ; Se-Hwa Kim^a ; ^b ; ^c ; ^{shkim@kriss.re.kr}
• 关键词：Fatty acids ; Size ; Lipid metabolism ; Lipotoxicity
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：100
• 期：Complete
• 页码：50-61
• 全文大小：4116 K
• 卷排序：100

文摘

Linoleic acid in micro- and nano-sizes were fabricated with well-stabilized sizes. Nanoscale, but not microscale, linoleic acid particles were internalized via FFAR3. Gene expression of InsR and adipoR1 was modulated by nanoscale FAs. Nanoscale linoleic acid induced acute cell death via increased ER stress.