Communication of cAMP by connexin43 gap junctions regulates osteoblast signaling and gene expression
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- 作者：Aditi Gupta ; Hidayah Anderson ; Atum M. Buo ; Megan C. Moorer ; Margaret Ren ; Joseph P. Stains ; jstains@som.umaryland.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gap junction ; Prostaglandin E2 ; Osteoblast ; G protein ; Cyclic AMP (cAMP) ; Connexin
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：28
- 期：8
- 页码：1048-1057
- 全文大小：1419 K
文摘
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Cx43 potentiates cAMP-dependent signaling in osteoblasts in a physiologic context.
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Cx43 can communicate cAMP between osteoblasts in a Cx43- and cell contact-dependent manner.
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Communication of cAMP by Cx43 is sufficient to affect signaling and osteoblast gene expression.