Fabrication of BioFET linear array for detection of protein interactions

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• 作者：Ling Wang ; Pedro Estrela ; Ejaz Huq ; Peng Li ; Stephen Thomas ; Paul Ko Ferrigno ; Debjani Paul ; Paul Adkin ; Piero Migliorato
• 关键词：BioFETs ; Protein interaction ; SU-8
• 刊名：Microelectronic Engineering
• 出版年：2010
• 出版时间：May-August 2010
• 年：2010
• 卷：87
• 期：5-8
• 页码：753-755
• 全文大小：460 K

文摘

An extended-gate MOSFETs (metal–oxide-semiconductor field-effect transistors) based biosensing linear array has been fabricated for label-free protein interaction detection. The device was realized using a combination of very low leakage current MOSFET transistors and an external gate where the chemical reaction would take place. Peptide aptamers that recognize cyclin-dependent kinase (CDK), a protein cancer marker, were used as a biological test system. The test results showed a high sensitive in the detection of CDK.