Oligonucleotide aptamers: A next-generation technology for the capture and detection of circulating tumor cells
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- 作者：David D. Dickeya ; Paloma H. Giangrandea ; b ; paloma-giangrande@uiowa.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CTC ; circulating tumor cell ; FDA ; Federal Drug Administration ; EGFR ; Epidermal Growth Factor Receptor ; EpCAM ; epithelial cell adhesion molecule ; DAPI ; 4&prime ; 6-diamino-2-phenylindole ; NGS ; next-generation sequencing ; SELEX ; Systematic Evolution of Ligands By Exponential Enrichment ; RNA ; ribonucleic acid ; DNA ; deoxyribonucleic acid ; PSMA ; prostate specific membrane antigen ; HER2 ; human epidermal growth factor receptor 2 ; CEA ; carcinoembryonic antigen ; hnRNP A1 ; heterogeneous nuclear ribonucleop
- 刊名：Methods
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：97
- 期：Complete
- 页码：94-103
- 全文大小：1137 K
文摘
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Circulating tumor cells (CTCs) are important for the metastatic spread of cancer.
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Isolating and characterizing CTCs could provide valuable clinical information.
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Technologies to isolate and study CTCs have been extensively investigated.
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Aptamers have recently emerged as new and powerful tools to study CTCs.
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Here we provide a review on the use of aptamers in CTC research.