Breast Cancer in a 19-Year-Old Female Adolescent Identified with Li-Fraumeni Syndrome

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• 作者：Allison M. Jay ; MD ; ^{allyjcyprus@hotmail.com} ; Anthony S. Hamame ; MD ; Carrie Dul ; MD ; Cheryl Wesen ; MD
• 关键词：Breast cancer ; Young age ; Li-Fraumeni syndrome ; Ultrasound
• 刊名：Journal of Pediatric and Adolescent Gynecology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：30
• 期：1
• 页码：e5-e6
• 全文大小：188 K
• 卷排序：30

文摘

Breast cancer is rare in adolescents. In one study, breast carcinoma accounted for 0.02% of breast masses surgically removed in young women. We report a case of breast cancer in a 19-year-old woman who was found to have Li-Fraumeni Syndrome.CaseThe patient presented with a new, hard, nonmobile lump in the right breast which prompted her to seek medical attention. A biopsy identified invasive ductal carcinoma. Genetic testing showed a p53 mutation associated with Li-Fraumeni syndrome.Summary and ConclusionAlthough breast masses in young women are mostly benign, one must entertain the possibility of more serious conditions when a breast mass is identified with concerning medical or physical findings. Genetic testing might be informative for such patients.