The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly
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- 作者：Stuart J. Smitha ; Norma Towersa ; José ; W. Saldanhab ; Catherine A. Shanga ; S. Radma Mahmoodc ; William R. Taylorb ; Timothy J. Mohuna ; tim.mohun@crick.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adprhl1 ; Heart ; Ventricle ; Myofibril ; Morpholino ; Transgenic
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：416
- 期：2
- 页码：373-388
- 全文大小：6179 K
文摘
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Adprhl1 is expressed exclusively in the heart of all vertebrates.
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Morpholino knockdown of Adprhl1 prevents outgrowth of the ventricle.
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Elevated 40 kDa Adprhl1 produces disarrayed myofibrils that show extensive branching.
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The 5′-coding sequence of Xenopus adprhl1 influences the synthesis of Adprhl1 protein.
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Two Adprhl1 proteins, 40+23 kDa exist in Xenopus embryos and are conserved in mouse.