Involvement of Opioid Receptors and α2-Adrenoceptors in Inhibitory Pain Modulation Processes: A Double-Blind Placebo-Controlled Crossover Study
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- 作者：Lechi Vo&lowast ; ; Sean Hood&dagger ; ; Peter D. Drummond&lowast ; ; p.drummond@murdoch.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：High-frequency electrical stimulation ; central sensitization ; conditioned pain modulation ; opioid receptors ; α2-adrenoceptors
- 刊名：The Journal of Pain
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：17
- 期：11
- 页码：1164-1173
- 全文大小：649 K
文摘
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Limb pain evokes an ipsilateral form of conditioned pain modulation.
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Opioid peptides mediate this response in the painful limb and ipsilateral forehead.
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20">These inhibitory opioid influences override opposing α2-adrenoceptor effects.
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25">Failure of this ipsilateral opioid response may aggravate chronic limb or head pain.