Activation of corticotropin-releasing factor neurons and microglia in paraventricular nucleus precipitates visceral hypersensitivity induced by colorectal distension in rats
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- 作者：Gongliang Zhangc ; 1 ; Le Yua ; 1 ; Zi-Yang Chena ; 1 ; Jun-Sheng Zhua ; Rong Huab ; Xia Qina ; Jun-Li Caoa ; ; Yong-Mei Zhanga ; zhangym700@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AWR ; abdominal withdrawal reflect ; ACTH ; adrenocorticotrophin hormone ; CORT ; corticosterone ; CRF ; corticotropin-releasing factor ; CRD ; colorectal distension ; EDTA ; ethylenediaminetetraacetic acid ; EMG ; electromyography ; HPA ; hypothalamic&ndash ; pituitary&ndash ; adrenal axis ; IBS ; irritable bowel syndrome ; IκB ; inhibitor of kappa B ; IL-1β ; interleukin-1β ; MyD88 ; myeloid differentiation factor 88 ; LPS ; lipopolysaccharide ; NF-κB ; nuclear factor κB ; PVN ; paraventricular nucleus ; qRT-PCR ; quantitative
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：93-104
- 全文大小：4944 K
文摘
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Role of microglia and CRF neurons in PVN on visceral hypersensitivity is unclear.
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Inhibition of PVN CRF neurons suppresses visceral hypersensitivity in rats.
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Visceral hypersensitivity is related to microglial and TLR4 signaling hyperactivity.
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Microglial inhibition suppresses CRF neuronal and visceral hypersensitivity.