The feto-placental unit, and potential roles of dehydroepiandrosterone (DHEA) in prenatal and postnatal brain development: A re-examination using the spiny mouse
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- 作者：Tracey A. Quinna ; b ; Udani Ratnayakea ; c ; Hayley Dickinsona ; b ; Margie Castillo-Melendeza ; b ; c ; David W. Walkera ; b ; david.walker@hudson.org.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：3β-HSD ; 3β-hydroxysteroid dehydrogenase ; 17-OH-PREG ; 17-hydroxypregnenolone ; ACTH ; adrenocorticotrophic hormone ; CNS ; central nervous system ; CRH ; corticotropin releasing hormone ; DHEA ; dehydroepiandrosterone ; DHEA-S ; dehydroepiandrosteronesulphate ; GABA ; gamma-aminobutyric acid ; H & E ; haemotoxylin and eosin ; HPA ; hypothalamic-pituitary-adrenal axis ; MR ; mineralocorticoid receptor ; NMDA ; N-methyl-d-aspartic acid ; P450c17 ; 17-hydroxylase/17 ; 20-lyase ; P450scc ; cholesterol side-chain cleavage enzy
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：204-213
- 全文大小：1016 K
文摘
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The androgen dehydroepiandrosterone (DHEA) is an important steroid produced by the adrenal gland during fetal development.
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DHEA and its sulphated derivative DHEAS provides estrogen derivatives in maternal serum that allows feto-placental development to be monitored during human pregnancy.
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DHEA synthesis has also been observed in a rodent-like species, the spiny mouse (Acomys cahirinus).
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DHEA synthesis in the spiny mouse brain changes from predominantly neuronal in fetal life to white matter in the adult brain.
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Coordinate changes in the localisation of DHEA synthesis and glucocorticoid receptor (GR) expression in the spiny mouse suggests a functional linkage between DHEA and the GR in development.